CAS NO: 52-1-7
Einecs No: 200-133-6
Appearance: White or white crystal powder of fine;Slightly bitter taste, odourless or slightly mercaptan odor.Insoluble in water, soluble in ethanol, soluble in benzene or ethyl acetate.
Usage: Spironolactone is competitive inhibition of aldosterone drugs, drug itself is not active, role is diuresis and endogenous competitive aldosterone antagonist and happen, belongs to the potassium diuretics.
|Test Items||Specification||Test Results|
|Appearance||Almost white crystalline powder||Almost white crystalline powder|
|Identification||Meet the requirements||Meet the requirements|
|Melting range||Between 198℃ and 209℃||205.0℃~207.0℃|
|Specific rotation||Between -33° and -37°||-35°|
|Loss on drying||Not more than 0.5%||0.2%|
|Limit of mercapto compounds||Meet the requirements||Meet the requirements|
|Ordinary impurities||Meet the requirements||Meet the requirements|
|Organic volatile impurities||Meet the requirements||Meet the requirements|
|Assay（on the dried basis）||Between 97.0% and 103.0%||98.99%|
|Conclusion||Meet the requirements of USP29|