aldosterone drugs Spironolactone Antisterone

Spironolactone

Alias: Aldactone;Antisterone;spirolactone
CAS NO: 52-1-7
Einecs No: 200-133-6
MF: C24H32O4S
MW: 416.58

Purity: 98.0%
Appearance:  White or white crystal powder of fine;Slightly bitter taste, odourless or slightly mercaptan odor.Insoluble in water, soluble in ethanol, soluble in benzene or ethyl acetate.

Usage: Spironolactone is competitive inhibition of aldosterone drugs, drug itself is not active, role is diuresis and endogenous competitive aldosterone antagonist and happen, belongs to the potassium diuretics.

Specifications:

Test Items Specification Test Results
Appearance Almost white crystalline powder Almost white crystalline powder
Identification Meet the requirements Meet the requirements
Melting range Between 198℃ and 209℃ 205.0℃~207.0℃
Specific rotation Between -33° and -37° -35°
Loss on drying Not more than 0.5% 0.2%
Limit of mercapto compounds Meet the requirements Meet the requirements
Ordinary impurities Meet the requirements Meet the requirements
Organic volatile impurities Meet the requirements Meet the requirements
Assay(on the dried basis) Between 97.0% and 103.0% 98.99%
Conclusion Meet the requirements of USP29

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